Natural human antibody responses to Plasmodium vivax apical membrane antigen 1 under low transmission and unstable malaria conditions in Sri Lanka.

نویسندگان

  • Thilan Wickramarachchi
  • Prasad H Premaratne
  • K L R Lakshman Perera
  • Sumith Bandara
  • Clemens H M Kocken
  • Alan W Thomas
  • Shiroma M Handunnetti
  • Preethi V Udagama-Randeniya
چکیده

Plasmodium vivax apical membrane antigen 1, an important malaria vaccine candidate, was immunogenic during natural malaria infections in Sri Lanka, where low transmission and unstable malaria conditions prevail. Antibody prevalence increased with exposure in areas where malaria was or was not endemic. A marked isotype switch to cytophilic (immunoglobulin G1 [IgG1]/IgG3) antibodies was evident with increasing exposure exclusively in residents from areas of endemicity.

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عنوان ژورنال:
  • Infection and immunity

دوره 74 1  شماره 

صفحات  -

تاریخ انتشار 2006